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Effects of resistin on insulin signaling in endothelial cells

Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 136-140 doi: 10.1007/s11684-009-0029-2

Abstract: Akt and endothelial nitric oxide synthase (eNOS) phosphorylation levels of endothelial cells under basalThe results showed that resistin could significantly inhibit Akt and eNOS phosphorylation and NO productionresult in a decrease in eNOS phosphorylation ( < 0.05 control) but had no effect on NO production and Akt

Keywords： resistin     endothelium     nitric oxide     endothelial nitric oxide synthase     Akt-binding protein     mouse    

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Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 378-388 doi: 10.1007/s11684-021-0840-y

Abstract: The Fc fragment of the IgG-binding protein (FCGBP) was identified as the most promising indicator of

Keywords： severe Mycoplasma pneumoniae pneumonia     children     proteomics     Fc fragment of the IgG-binding protein    

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Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11705-014-1454-6

Abstract: The aggregation of amyloid -protein (A ) is tightly linked to the pathogenesis of Alzheimer’s diseaseHowever, atomic details of binding modes and binding affinities between these peptide inhibitors andAll inhibitors exhibit varied binding affinity to A , in which KLVFF has the highest binding affinityThis work provides structure-based binding information for further modification and optimization of thesethree peptide inhibitors to enhance their binding and inhibitory abilities against A aggregation.

Keywords： Alzheimer’s disease     amyloid β-protein     peptide inhibitors     protein-protein interaction     molecular    

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Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 26-29 doi: 10.1007/s11684-009-0008-7

Abstract: clone formation assay, and western blot was applied to detect the expressions of Ku80, DNA-PKcs and ATM proteinThe correlativity of protein expression with SF2 value was analyzed by Pearson linear correlation analysisWe found that the expression of same protein in different cell lines and the expression of three proteinsThese findings suggest that the expression level of DNA-PKcs protein can be an indicator for predicting

Keywords： Ku80     DNA-PK(cs)-binding protein     human     ataxia telangiectasia mutated protein     tumor cell lines     radiosensitivity    

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Protein adsorption in two-dimensional electrochromatography packed with superporous and microporous cellulose

Dongmei WANG, Guodong JIA, Liang XU, Xiaoyan DONG, Yan SUN

Frontiers of Chemical Science and Engineering 2009, Volume 3, Issue 3,   Pages 229-234 doi: 10.1007/s11705-009-0213-6

Abstract: The dynamic binding capacity (DBC) in the presence of 2D eEF was higher than in the presence of a one-dimensional2D electrochromatography packed with the superporous cellulose adsorbent is promising for high-speed protein

Keywords： electrochromatography     two-dimensional electric field     dynamic binding capacity     superporous cellulose bead     protein    

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Regulation of NLR stability in plant immunity

Tao WANG, Jiaxin LI, Qian-Hua SHEN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 2,   Pages 97-104 doi: 10.15302/J-FASE-2018248

Abstract:

Plant nucleotide binding domain and leucine-rich repeat (NLR) receptors recognize pathogen effectorsThe N-end rule pathway of protein degradation is also directly linked to NLR stability.

Keywords： E3 ubiquitin ligase     degradation     nucleotide-binding leucine-rich repeat receptor     plant immunity     proteasome     protein stability     ubiquitination    

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GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Frontiers of Medicine 2023, Volume 17, Issue 1,   Pages 119-131 doi: 10.1007/s11684-022-0949-7

Abstract: GDF15 improved the tolerance of ESCC cell lines to low-dose cisplatin by regulating AKT phosphorylationAKT and TGFBR2 inhibition resulted in the reversal of the GDF15-induced expression of UGT1A, indicatingthat TGFBR2-AKT pathway-dependent metabolic pathways were involved in the resistance of ESCC cells to

Keywords： GDF15     esophageal squamous cell carcinoma     chemoresistance     cellular metabolism     TGFBR2     AKT    

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Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT

LI Yanhua, BI Zhigang

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 79-86 doi: 10.1007/s11684-007-0016-4

Abstract: HIF-1α protein was measured by Western blot method.Results showed that compared with control groups, UVB was able to induce HIF1α and TfR protein expressionThe EGFR/PI3K/AKT signaling pathway was required for the induction of HIF-1α and TfR expression inducedprotein expression after UVB irradiation (P<0.05).We conclude that UVB induces TfR and HIF-1αexpressions via EGFR/PI3K/AKT/DEC1 signaling pathway.
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Chloride binding and time-dependent surface chloride content models for fly ash concrete

S. MUTHULINGAM,B. N. RAO

Frontiers of Structural and Civil Engineering 2016, Volume 10, Issue 1,   Pages 112-120 doi: 10.1007/s11709-015-0322-x

Abstract: fly ash concrete, namely: 1) surface chloride content under tidal exposure condition; and 2) chloride bindingFirst, inconsistencies in surface chloride content and chloride binding models reported in literatureSecondly, to avoid such inconsistencies, surface chloride content and chloride binding models for fly

Keywords： binding isotherms     chloride ingress     concrete     fly ash     surface chloride content    

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Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 688-696 doi: 10.1007/s11684-018-0662-8

Abstract: Moreover, XKQ can ameliorate insulin resistance and upregulate the expression of IRS-1, PI3K (p85), p-AktXKQ is an effective drug for T2DM by ameliorating insulin resistance and regulating the PI3K/Akt signaling

Keywords： XKQ     type 2 diabetes mellitus     KKAy mice     PI3K/Akt pathway     diabetic liver disease    

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Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 730-740 doi: 10.1007/s11684-019-0687-7

Abstract: GATA binding protein 3 (GATA3) and mismatch repair (MMR) deficiency contribute to the development of

Keywords： upper tract urothelial carcinoma     GATA binding protein 3     mismatch repair     microsatellite instability     prognosis    

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Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 341-346 doi: 10.1007/s11684-009-0067-9

Abstract: LY294002, an inhibitor of PI3K in cervical cancer cells and the expression of FLICE-like inhibitory proteinThese results suggested that the PI3K/Akt signal pathway might be involved in the regulation of cellMoreover, the regulation of c-FLIP expression through PI3K/Akt signal pathway in cervical cancer cells

Keywords： human cervical cancer cells     apoptosis     phosphatidylinositol 3-kinase (PI3K)/Akt     FLICE-like inhibitoryprotein    

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reduces IgE binding ability of allergenic egg white proteins

Sen LI, Marina OFFENGENDEN, Michael G. GÄNZLE, Jianping WU

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 3,   Pages 373-381 doi: 10.15302/J-FASE-2018210

Abstract: objective of this study was to investigate the effect of Aspergillus oryzae cultivation on IgE bindingAdding mycelium of A. oryzae ATCC 1011 and 16868 substantially reduced the IgE binding abilityThe binding capacity of egg white proteins to IgE in plasma from four egg allergy patients was almostSDS-PAGE, free amino acid analysis, MALDI-TOF-MS and LC-MS/MS indicated that there was no substantial proteinTherefore, the reduction of IgE binding ability of egg white proteins during A. oryzae treatment

Keywords： Aspergillus oryzae     egg allergy     egg white proteins     IgE-binding ability     ovomucoid    

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Quantitative characterization of Cu binding potential of dissolved organic matter (DOM) in sediment from

Yuan ZHANG,Yan ZHANG,Tao YU

Frontiers of Environmental Science & Engineering 2014, Volume 8, Issue 5,   Pages 666-674 doi: 10.1007/s11783-013-0608-y

Abstract: sediment samples were collected from various part of Taihu Lake to explore the spatial difference in the bindingThe ISE results showed that the exogenous DOM had higher binding ability than endogenous DOM, and DOMderived from aquatic macrophytes had a higher binding ability than that derived from algae.However, because of the frequent breakout of algae blooms, protein-like matters are also main componentTherefore, the metals bound by protein-like substances should be caused concern as protein-like substances

Keywords： binding ability     dissolved organic matters     fluorescence quenching     complex capacity     Taihu Lake    

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Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block

Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 420-429 doi: 10.1007/s11684-016-0478-3

Abstract: as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion proteinFurthermore, all-trans retinoic acid treatment induced CDKN2C expression by releasing the PML/RARα binding

Keywords： CDKN2C     acute promyelocytic leukemia     cell cycle arrest     differentiation    

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Title Author Date Type Operation

Effects of resistin on insulin signaling in endothelial cells

Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU

Journal Article

Proteomics study of Mycoplasma pneumoniae pneumonia reveals the Fc fragment of the IgG-binding protein

Journal Article

Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Journal Article

Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity

Liang ZHUANG, Shiying YU, Xiaoyuan HUANG, Yang CAO, Huihua XIONG

Journal Article

Protein adsorption in two-dimensional electrochromatography packed with superporous and microporous cellulose

Dongmei WANG, Guodong JIA, Liang XU, Xiaoyan DONG, Yan SUN

Journal Article

Regulation of NLR stability in plant immunity

Tao WANG, Jiaxin LI, Qian-Hua SHEN

Journal Article

GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal

Journal Article

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT

LI Yanhua, BI Zhigang

Journal Article

Chloride binding and time-dependent surface chloride content models for fly ash concrete

S. MUTHULINGAM,B. N. RAO

Journal Article

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Journal Article

Expression status of GATA3 and mismatch repair proteins in upper tract urothelial carcinoma

Yue Wang, Jinxia Zhang, Yunfan Wang, Shufang Wang, Yu Zhang, Qi Miao, Fei Gao, Huiying He

Journal Article

Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells

Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,

Journal Article

reduces IgE binding ability of allergenic egg white proteins

Sen LI, Marina OFFENGENDEN, Michael G. GÄNZLE, Jianping WU

Journal Article

Quantitative characterization of Cu binding potential of dissolved organic matter (DOM) in sediment from

Yuan ZHANG,Yan ZHANG,Tao YU

Journal Article

Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block

Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang

Journal Article